There are several different genetic tests out there, many of them only test for specific genes but there's one I did at 23andme that tests for hundreds of thousands of genes and their website has all kinds of information and reports that tell you if you have increased risk of certain diseases or any inherited conditions. It even has a relative finder. The test used to be $299 but they lowered the price to $99 at the beginning of the year which is one heck of a deal. They also recently started a referral program so if you're interested in the test, I encourage you to use this 23andme link and I get a $10 Amazon gift card. :)
23andme provides you with the raw data too which is a text file you can import into various applications that will provide you with more detailed reports. Some of these applications have a small fee and others are available for free. I did this test for the methylation genes which are important for detoxification, immune function, mood and just general health. Without a good functioning methylation pathway, you are at high risk for getting very sick. Knowing which genes you have in this methylation pathway can help you avoid health issues. If you already have health issues it becomes an important tool in figuring out what genes may be turned on and causing them. Below are a couple of good apps I would recommend that pulls the methylation and other genes from your raw data and some provide health reports.
- Genetic Genie - free and includes 31 genes related to methylation. See a sample report.
- MTHFRsupport - $20 and includes genes related to methylation, allergies, mitochondrial, thyroid, detox, clotting and more. You can also contact them and they will go over the report with you and tell you what each gene's function is in more detail. If you don't want to pay for a consultation, another option is listening to this BlogTalkRadio interview where they go over many of them in detail. See a sample report.
- Livewello - The Livewello Gene Reporting tool uses your Raw Data Genome from 23andme to generate a Gene Variance report which contains information on thousands of disease related genes.Cost is $19.95
- Promethease - For $5 offers a variety of health information based on your 23andme results. See a sample report.
I posted my methylation results before in a different blog post here. It is interesting to see how my lab test results I had done correlate with the genes I have. For example, one of the genes in the MTHFRsupport report is CTH S4031I (rs1021737 from 23andme) and this gene produces an enzyme that converts Cystathionine to Cysteine. In the Metametrix ION profile I had done it showed my Cystathionine level was very high which makes sense because I am +/+ in that gene. B6 is the supplement that aids in that conversion process so that should help lower my cystathionine and get things moving in the right direction. I found several instances in lab testing that confirmed that several of my genes are being expressed (turned on) which has helped in identifying what supplements I need to take to improve my health.
This is a handy methylation map that shows many of the genes in the cycle. There are a lot of different diagrams out there but I found this one the most helpful. The blue boxes are the methylation genes. I'm not familiar with SAHH and DHPR. I haven't come across those in any of the research I've done so not sure what their role is. I highlighted the ones that I have on a printout and brought the diagram to my ND to show her because she wasn't very familiar with it. In this map I have BHMT, MTRR, CBS, MTHFR, MAOA and COMT. I think I probably have a little more than most people. There are other genes involved besides these but these seem to be the most important ones.
1st priority: ACAT, SHMT and CBS. Note that ACAT and SHMT are not pictured in the diagram. They are related to gut disbiosis and imbalanced flora and CBS can cause an upregulation of homocysteine, creating toxic levels of ammonia and sulfites.
2nd priority: COMT, MTR, MTRR, MTHFR, NOS and SUOX. AHCY, BHMT and PEMT have also recently been added as 2nd priority mutations. BHMT is the methylation shortcut so if you have MTR and/or MTRR mutations BHMT should be supported first to get the cycle going. This is done with supplementing with TMG as noted in the diagram. This is the step I'm currently at because I have 4 of the 6 MTRR mutations. Eventually I'll be able to start supporting the other 2nd priority mutations with active forms of folate and B12.
Other: SUOX, MAO A, NOS, ACE, PEMT. I have MAO A which breaks down serotonin. They call it the warrior gene because it can cause aggression, violation and antisocial behaviors. I also have PEMT which can cause problems converting phosphatidylethanolamine to phosphatidylcholine so am taking sunflower lecithin which contains high levels of choline. I have already noticed since taking it that I am able to remember my dreams easier than I used to.
You can learn more about each of these mutations in Chapter 6 of Dr. Amy Yasko's Autism Pathways to Recovery e-book.